Therapeutic Interventions in the Complement System by John D. Lambris (English)

Description: Therapeutic Interventions in the Complement System by John D. Lambris, V. Michael Holers A team of expert investigators and clinical researchers comprehensively review complements basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients. FORMAT Hardcover LANGUAGE English CONDITION Brand New Publisher Description A team of expert investigators and clinical researchers comprehensively review complements basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients. Each chapter focuses on a specific area of basic and applied complement biology, spelling out the activation pathways and complement receptors. Informative animal models are discussed in detail, including the relative values of each model and the important interspecies differences that can distort the interpretation of preclinical studies. The emphasis throughout is on the pros and cons of the therapeutic use of recombinant complement inhibitors in specific diseases. Cutting-edge and innovative, Therapeutic Interventions in the Complement System highlights for todays researcher and biotechnologist effective strategies of drug discovery and development that are producing valuable new complement inhibitors for the treatment of a wide variety of clinically important diseases. Back Cover Although the complement system is a vital part of the bodys defenses against bacteria, its inappropriate activation produces the cell damage found in a wide variety of illnesses, ranging from hemolytic anemia to multiple sclerosis. In Therapeutic Interventions in the Complement System, a team of expert investigators and researchers comprehensively review complements basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients. Each chapter focuses on a specific area of basic and applied complement biology, detailing the activation pathways and complement receptors. Informative animal models are thoroughly discussed, including the relative values of each model and the important interspecies differences that can distort the interpretation of preclinical studies. Also discussed are analytical issues concerning the sensitivity and specificity of the important new ELISA assays for measuring complement. Throughout, the emphasis is on the pros and cons of the use of recombinant complement inhibitors as therapeutics in specific diseases. Cutting-edge and innovative, Therapeutic Interventions in the Complement System highlights for clinical researchers and biotechnologists the powerful drug discovery and development strategies that are producing the novel complement inhibitors today emerging for the treatment of a wide variety of clinically important diseases. Table of Contents 1 Complement as a Regulatory and Effector Pathway in Human Diseases.- 2 The Regulation of C1 Activation and its Role in Disease.- 3 Inhibition of Complement Serine Proteases as a Therapeutic Strategy.- 4 Complement Inhibitors Targeting C3, C4, and C5.- 5 Complement Anaphylatoxins (C3a, C4a, C5a) and Their Receptors (C3aR, C5aR/CD88) as Therapeutic Targets in Inflammation.- 6 Modulation of Disease Using Recombinant Human Endogenous Complement Inhibitors.- 7 Roles of Integrins CR3 and CR4 in Disease and Therapeutic Strategies.- 8 Inhibition of Complement in the Membrane Attack Pathway.- 9 Evaluation of Complement Inhibitors.- 10 Use of Animal Models to Define Complement Functions. Long Description A team of expert investigators and clinical researchers comprehensively review complements basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients. Each chapter focuses on a specific area of basic and applied complement biology, spelling out the activation pathways and complement receptors. Informative animal models are discussed in detail, including the relative values of each model and the important interspecies differences that can distort the interpretation of preclinical studies. The emphasis throughout is on the pros and cons of the therapeutic use of recombinant complement inhibitors in specific diseases. Cutting-edge and innovative, Therapeutic Interventions in the Complement System highlights for todays researcher and biotechnologist effective strategies of drug discovery and development that are producing valuable new complement inhibitors for the treatment of a wide variety of clinically important diseases. Feature Includes supplementary material: sn.pub/extras Details ISBN0896035875 Short Title THERAPEUTIC INTERVENTIONS IN T Language English ISBN-10 0896035875 ISBN-13 9780896035874 Media Book Format Hardcover DEWEY 616.079 Year 2000 Series Contemporary Immunology Place of Publication Totowa, NJ Country of Publication United States Author V. Michael Holers Imprint Humana Press Inc. Pages 260 Edited by V. Michael Holers Illustrations X, 260 p. DOI 10.1226/0896035875;10.1007/978-1-59259-017-9 AU Release Date 2000-04-15 NZ Release Date 2000-04-15 US Release Date 2000-04-15 UK Release Date 2000-04-15 Publisher Humana Press Inc. Edition Description 2000 ed. Edition 2000th Publication Date 2000-04-15 Alternative 9781468496123 Audience Undergraduate We've got this At The Nile, if you're looking for it, we've got it. With fast shipping, low prices, friendly service and well over a million items - you're bound to find what you want, at a price you'll love! TheNile_Item_ID:96277240;

Price: 220.33 AUD

Location: Melbourne

End Time: 2024-12-08T12:52:53.000Z

Shipping Cost: 20.49 AUD