Introducing Proteomics: From Concepts to Sample Separation, Mass Spectrometry an

Description: FREE SHIPPING UK WIDE Introducing Proteomics by Josip Lovric *Contemporary, Broad Coverage covers every aspect of the rapidly changing field of proteomics from *Coherent and Student friendly based on the highly successful course developed by the author at Manchester University. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Introducing Proteomics gives a concise and coherent overview of every aspect of current proteomics technology, which is a rapidly developing field that is having a major impact within the life and medical sciences. This student-friendly book, based on a successful course developed by the author, provides its readers with sufficient theoretical background to be able to plan, prepare, and analyze a proteomics study. The text covers the following: Separation TechnologiesAnalysis of Peptides/Proteins by Mass SpectrometryStrategies in Proteomics This contemporary text also includes numerous examples and explanations for why particular strategies are better than others for certain applications. In addition, Introducing Proteomics includes extensive references and a list of relevant proteomics information sources; essential for any student. This no-nonsense approach to the subject tells students exactly what they need to know, leaving out unnecessary information. The student companion site enhances learning and provides answers to the end of chapter problems. "I think this book will be a popular and valuable resource for students and newcomers to the field who would like to have an overview and initial understanding of what proteomics is about. The contents are well organized and address the major issues." —Professor Walter Kolch, Director, Systems Biology Ireland & Conway Institute, University College Dublin Companion Website Back Cover Introducing Proteomics provides an accessible introduction to current proteomics technology, including all of the background information necessary to enable readers to plan, prepare and analyze proteomics studies. Engaging and packed with expert advice, this indispensable guide will appeal to both students and researchers new to the field alike. Key Features: Contemporary, broad coverage - covers every important aspect of this rapidly changing field from 2-d gel electrophoretic methods, peptide based shotgun proteomics, the main ionization methods and detailed mass spectrometric principles and applications as well as an introduction to the use of protein/RNA and DNA databases to data analysis and the main features of proteomics data mining software. Coherent and student friendly - focuses on what readers need to know about each area of proteomics whilst providing pointers towards more specialized literature for those that are keen to find out more. Relevant - explores the power and limitations of current proteomics approaches throughout the book to give readers a realistic idea about which results and challenges to expect from any combination of technologies. The concluding part of the book explores real-world case studies to illustrate how proteomics technologies perform in practice whilst dedicated chapters focus on the analysis of post translational modifications and biomarker discovery. Companion website - provides a range of problems for self testing with answers, extensive references and links to additional, key proteomics resources. I think this book will be a popular and valuable resource for students and newcomers to the field who would like to have an overview and initial understanding of what proteomics is about. The contents are well organized and address the major issues. - Professor Walter Kolch, Director, Systems Biology Ireland & Conway Institute, University College Dublin Companion Website Flap Introducing Proteomics provides an accessible introduction to current proteomics technology, including all of the background information necessary to enable readers to plan, prepare and analyze proteomics studies. Engaging and packed with expert advice, this indispensable guide will appeal to both students and researchers new to the field alike. Key Features: Contemporary, broad coverage - covers every important aspect of this rapidly changing field from 2-d gel electrophoretic methods, peptide based shotgun proteomics, the main ionization methods and detailed mass spectrometric principles and applications as well as an introduction to the use of protein/RNA and DNA databases to data analysis and the main features of proteomics data mining software. Coherent and student friendly - focuses on what readers need to know about each area of proteomics whilst providing pointers towards more specialized literature for those that are keen to find out more. Relevant - explores the power and limitations of current proteomics approaches throughout the book to give readers a realistic idea about which results and challenges to expect from any combination of technologies. The concluding part of the book explores real-world case studies to illustrate how proteomics technologies perform in practice whilst dedicated chapters focus on the analysis of post translational modifications and biomarker discovery. Companion website - provides a range of problems for self testing with answers, extensive references and links to additional, key proteomics resources. I think this book will be a popular and valuable resource for students and newcomers to the field who would like to have an overview and initial understanding of what proteomics is about. The contents are well organized and address the major issues. - Professor Walter Kolch, Director, Systems Biology Ireland & Conway Institute, University College Dublin Companion Website Author Biography Josip Lovric is the author of Introducing Proteomics: From Concepts to Sample Separation, Mass Spectrometry and Data Analysis, published by Wiley. Table of Contents Preface ix Acknowledgements xi 1 Introduction 1 1.1 What Are the Tasks in Proteomics? 1 1.2 Challenges in Proteomics 5 1.3 Proteomics in Relation to Other -omics and System Biology 10 1.4 Some General Applications of Proteomics 12 1.5 Structure of the Book 18 References 18 2 Separation and Detection Technologies 21 2.1 Introduction to Experimental Strategies in Proteomics 21 2.2 Gel-Based Separation 31 2.3 Visualization and Analysis of Proteins/Peptides in Gels 40 2.4 Gel-Free Separation Technologies 54 2.5 Visualization of Proteins/Peptides from Hyphenated Methods 74 2.6 Chips in Proteomic Applications 81 References 81 3 Analysis of Peptides/Proteins by Mass Spectrometry 83 3.1 Basic Principles of Mass Spectrometry for Proteomics 83 3.2 Ionization Methods for Small Amounts of Biomolecules 101 3.3 Mass Analyzers and Mass Spectrometers 116 3.4 Concluding Remarks on Mass Analyzers for Proteomics 170 References 170 4 Analysis and Interpretation of Mass Spectrometric and Proteomic Data 173 4.1 Introduction 173 4.2 Analysis of MS Data 174 4.3 Analysis of MS/MS Data 192 4.4 Quantification of LC MS and MS/MS Data from Complex Samples 209 4.5 Bioinformatic Approaches for Mass Spectrometric Proteome Data Analysis 213 References 218 5 Strategies in Proteomics 221 5.1 Imaging Mass Spectrometry 221 5.2 Qualitative Proteomics 223 5.3 Differential and Quantitative Proteomics 234 5.4 Analysis of Posttranslational Modifications 257 5.5 Interaction Proteomics 261 5.6 Proteomics as Part of Integrated Approaches 266 References 271 Index 275 Long Description Introducing Proteomics provides an accessible introduction to current proteomics technology, including all of the background information necessary to enable readers to plan, prepare and analyze proteomics studies. Engaging and packed with expert advice, this indispensable guide will appeal to both students and researchers new to the field alike. Key Features: Contemporary, broad coverage covers every important aspect of this rapidly changing field from 2-d gel electrophoretic methods, peptide based shotgun proteomics, the main ionization methods and detailed mass spectrometric principles and applications as well as an introduction to the use of protein/RNA and DNA databases to data analysis and the main features of proteomics data mining software. Coherent and student friendly focuses on what readers need to know about each area of proteomics whilst providing pointers towards more specialized literature for those that are keen to find out more. Relevant explores the power and limitations of current proteomics approaches throughout the book to give readers a realistic idea about which results and challenges to expect from any combination of technologies. The concluding part of the book explores real-world case studies to illustrate how proteomics technologies perform in practice whilst dedicated chapters focus on the analysis of post translational modifications and biomarker discovery. Companion website provides a range of problems for self testing with answers, extensive references and links to additional, key proteomics resources. I think this book will be a popular and valuable resource for students and newcomers to the field who would like to have an overview and initial understanding of what proteomics is about. The contents are well organized and address the major issues. Professor Walter Kolch, Director, Systems Biology Ireland & Conway Institute, University College Dublin Companion Website Details ISBN0470035242 Author Josip Lovric ISBN-10 0470035242 ISBN-13 9780470035245 Format Paperback Subtitle From Concepts to Sample Separation, Mass Spectrometry and Data Analysis DEWEY 572.6 Short Title INTRODUCING PROTEOMICS Language English Media Book Illustrations Yes Affiliation University of Manchester Edition 1st Country of Publication United States Imprint John Wiley & Sons Inc Place of Publication New York AU Release Date 2011-02-04 NZ Release Date 2011-02-04 US Release Date 2011-02-04 UK Release Date 2011-02-04 Pages 304 Publisher John Wiley & Sons Inc Year 2011 Publication Date 2011-02-04 Alternative 9780470035238 Audience Undergraduate We've got this At The Nile, if you're looking for it, we've got it. 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