Description: Interaction of Mycophenolic Acid and Pantoprazole Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). A Pharmacokinetic Crossover Study Author(s): Olesja Rissling Format: Paperback Publisher: Springer Fachmedien Wiesbaden, Germany Imprint: Springer Spektrum ISBN-13: 9783658198886, 978-3658198886 Synopsis Olesja Rissling analyzes the potential interaction of mycophenolic acid (MPA) and pantoprazole. MPA is used as an immunosuppressive drug to prevent acute organ rejections after organ transplantation. Pantoprazole, known to interact with the bioavailability of drugs, is used to prevent upper gastrointestinal disorders. The author performed a clinical pharmacokinetic study in renal transplant patients to evaluate a potential interaction of MPA and pantoprazole. The bioavailability and the maximum concentration of MPA were determined with or without pantoprazole intake. An influence on the immunosuppressive effect was evaluated by measuring the target enzyme activity. Overall, no significant change in the bioavailability or the maximum concentration was found. Similar results were obtained for the target enzyme activity after pantoprazole intake with MPA. The results suggest that the interaction of pantoprazole with MPA does not compromise the immunosuppressive effect to a clinically meaningful extent.
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Book Title: Interaction of Mycophenolic Acid and Pantoprazole
Number of Pages: 162 Pages
Publication Name: Interaction of Mycophenolic Acid and Pantoprazole: a Pharmacokinetic Crossover Study
Language: English
Publisher: Springer Fachmedien Wiesbaden
Item Height: 210 mm
Subject: Medicine
Publication Year: 2017
Type: Textbook
Item Weight: 2454 g
Author: Olesja Rissling
Item Width: 148 mm
Format: Paperback
