Description: Hepatic Encephalopathy and Nitrogen Metabolism by D. Häussinger, G. Kirchels, F. Schless Hepatic Encephalopathy and Nitrogen Metabolism is an interdisciplinary symposium bringing together basic science and clinical applications. It contains up-to-date research findings at the highest scientific level. FORMAT Paperback LANGUAGE English CONDITION Brand New Publisher Description Hepatic Encephalopathy and Nitrogen Metabolism is an interdisciplinary symposium bringing together basic science and clinical applications. It contains up-to-date research findings at the highest scientific level. Table of Contents Physiology and pathophysiology of astrocytes.- Water transport in the brain: basic concepts and astrocytic swelling.- Osmotic and Oxidative stress in hepatic encephalopathy.- NADPH oxidase is a major source of swelling-induced generation of reactive oxygen species in rat astrocytes.- Detoxification of hydrogen peroxide by astrocytes.- Glutamate release from astrocytes: impact on neuronal function.- Hepatic stellate cells and astrocytes: similarities and differences.- Localization and function of ATP-binding cassette C (ABCC/MRP) efflux pumps in human brain.- Glial mechanisms of axonal growth protection from ammonia.- Selenoprotein P: A link between liver and brain.- Pathogenesis of hepatic encephalopathy.- The peripheral benzodiazepine receptor and neurosteroids in the pathogenesis of hepatic encephalopathy and ammonia neurotoxicity.- Glutamatergic synaptic regulation deficit in liver failure: A review of molecular mechanisms.- Synaptic plasticity in animal models relevant for hepatic encephalopathy.- N-methyl-D-aspartate receptors in hyperammonaemia and hepatic encephalopathy.- Prehepatic portal hypertension and mitochondrial dysfunction in brain hippocampus.- Nuclear magnetic resonance studies in experimental animal models of hepatic encephalopathy.- The role of inflammation in hepatic encephalopathy.- Brain imaging in hepatic encephalopathy research.- Altered neural oscillations and synchronization: a pathophysiological hallmark of hepatic encephalopathy.- Neurotransmitter receptor alterations in hepatic encephalopathy.- Quantitative T1 and water content mapping in hepatic encephalopathy.- Central nervous system involvement in hepatitis C virus infection: what to measure?.- Localized magnetic resonance-correlated spectroscopy using two spectral dimensions: theoretical description and pilot investigation in hepatic encephalopathy.- New aspects of nitrogen metabolism.- Urea cycle disorders.- Pathophysiology of citrin deficiency.- Hepatic encephalopathy in organic acidurias: hyperammonaemia and energy failure.- Glutamine synthetase deficiency in the human.- Hepatic dysfunction and encephalopathy in inborn errors of metabolism.- Amino acids and mammalian target of rapamycin-dependent signalling.- Ceramide is a negative regulator of insulin action, nutrient uptake and protein synthesis in cultured rat skeletal muscle cells.- Ammonia transport in aquaporins: molecular mechanisms and clinical relevance.- Glutamine synthetase as a target of ?-catenin: new insights into hepatic heterogeneity.- Ammonia metabolism in liver cirrhosis.- Clinical assessment of hepatic encephalopathy.- Definition and assessment of low-grade hepatic encephalopathy.- Hepatic encephalopathy in acute liver failure.- Quality of life in chronic liver diseases and in hepatic encephalopathy.- Hyponatraemia: A risk factor of hepatic encephalopathy in cirrhosis.- Neuropsychological dysfunction in minimal hepatic encephalopathy: a review compared with own experience.- Computerized or paper-and-pencil psychometric tests for the assessment of hepatic encephalopathy?.- Neurophysiological basis of critical flicker frequency (CFF) analysis.- Critical assessment of the PHES test battery in patients with low-grade hepatic encephalopathy.- Treatment.- Evidence-based medicine and hepatic encephalopathy treatment.- Brain oedema in acute liver failure: mechanisms and therapeutic options.- Hepatic encephalopathy and artificial liver support systems.- Prometheus® — a new extracorporeal system for the treatment of liver failure.- Modulation of intestinal flora for the treatment ofhepatic encephalopathy in cirrhosis.- Prevention of hepatic encephalopathy after porto-systemic shunt.- Milestones in research on hepatic encephalopathy. Long Description Hepatic encephalopathy is a major complication of liver cirrhosis and acute liver failure and represents an important issue of clinical and socioeconomic relevance. Hyperammonemic syndromes due to inborn errors of metabolism can also trigger encephalopathy. Much effort has been devoted during recent decades to understand the pathogenesis of hepatic encephalopathy, not only at the level of molecular and cell biology, but also at the neurophysiological and neuropsychological level. Considerable advances in the understanding of the syndrome and its relation to nitrogen metabolism have been achieved since the introduction and application of modern techniques of cell and molecular biology, neurophysiology and functional brain imaging, including magnetencephalography, positron emission tomography and functional magnetic resonance imaging and spectroscopy. In addition, novel approaches for diagnosis and treatment of hepatic encephalopathy have been developed in recent years and our understanding of the basic mechanisms of ammonia metabolism and inborn hyperammonaemic states has improved considerably. Although many questions are still open, recent scientific advances strengthen the view that hepatic encephalopathy is a consequence of disturbed astroglial hydration and glia-neuronal communication with pathologically altered oscillatory electrical coupling and processing in the brain. The most recent developments in research on hepatic encephalopathy, inborn hyperammonaemic syndromes and nitrogen metabolism, including clinical aspects, were presented by international acknowledged experts in this active research field at the 12th International Symposium on Hepatic Encephalopathy, which was held from June 1 to 4, 2005 in Solingen, Schloss Burg, Germany. This book comprehensively summarizes the most important novel issues on hepatic encephalopathy and nitrogen metabolism and is of interest not only for scientists in the field, but also for interested clinicians. This update of present knowledge will provide a platform for future research in the field of hepatic encephalopathy and nitrogen metabolism. Feature Interdisciplinary symposium bringing together basic science and clinical applications Up-to-date research findings at the highest scientific level Details ISBN9400788576 ISBN-10 9400788576 ISBN-13 9789400788572 Format Paperback Publisher Springer Year 2014 Imprint Springer Place of Publication Dordrecht Country of Publication Netherlands DEWEY 610 Publication Date 2014-11-29 Edited by D. Häussinger Affiliation Heinrich-Heine-Universitat Short Title HEPATIC ENCEPHALOPATHY & NITRO Language English Media Book Edition 2006th Illustrations XXVI, 590 p. Pages 590 Author F. Schless Edition Description 2006 ed. 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ISBN-13: 9789400788572
Book Title: Hepatic Encephalopathy and Nitrogen Metabolism
Number of Pages: 590 Pages
Language: English
Publication Name: Hepatic Encephalopathy and Nitrogen Metabolism
Publisher: Springer
Publication Year: 2014
Subject: Medicine, Biology
Item Height: 235 mm
Item Weight: 937 g
Type: Textbook
Author: F. Schless, G. Kirchels, D. Haussinger
Item Width: 155 mm
Format: Paperback
